![]() However, conclusions about relative effectiveness are limited by the fact that these vaccines were not distributed evenly over time and distribution varied geographically. This finding has some biological plausibility given the difference in antibody responses elicited by these vaccines ( Steensels, August 2021 Collier, November 2021 Bajema, December 2021 ). Some studies directly comparing the relative effectiveness of these two mRNA vaccines have shown a slightly higher and/or more durable protective effect of the Moderna COVID-19 vaccine compared with the Pfizer-BioNTech COVID-19 vaccine ( Collier, November 2021 Tenforde, November 2021 Bajema, December 2021 Dickerman, January 2022 Risk, February 2022 ). This is likely true both for adult and pediatric populations ( see Emerging Variants page). Additionally, vaccine-induced antibodies appear to wane over time ( see Immunity page ). However, effectiveness against SARS-CoV-2 variants of concern, including Delta and Omicron, is lower than effectiveness against the ancestral strain of SARS-CoV-2. Studies of both vaccines have shown them to be highly effective in preventing symptomatic COVID-19 and safe after several months of follow-up.īoth the Pfizer-BioNTech and Moderna COVID-19 vaccines are highly effective against both symptomatic and severe COVID-19 across age groups and in diverse populations (see literature subsections for Pfizer-BioNTech and Moderna ).
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